Melphalan hydrochloride is used to treat multiple myeloma and ovarian cancer. It belongs to the group of drugs known as alkylating agents, which inhibit the production and replication of DNA in cancer cells. This medication is given orally or intravenously (IV). It is administered in IV form together with other chemotherapy medications as a part of a treatment programme. Melphalan hydrochloride often comes in the form of tablets for oral use. The medication is used in high-dose chemotherapy regimens for multiple myeloma, which are followed by autologous stem cell transplantation. It is utilised in palliative care to control symptoms and halt the spread of some tumours.